The 14th Conference on Halophilic Microorganisms will be held from the 23rd - 26th of November 2025 in Oaxaca Mexico. The conference will highlight the latest advances in research on halophilic microbes with sessions on diversity, climate change, genetics and molecular biology, osmoadaption and signal transduction, ecology of hypersaline environments, halophilic viruses, bioprocesses and emerging biotechnology, halophiles in space and extreme analogues, applied omics and synthetic biology, and halophiles in food, agriculture, and human health.